Efek
Klarifikasi Pertama*¹ di Dunia tentang Bagian dari Mekanisme Inaktivasi SARS-CoV-2 dengan Teknologi nanoe™ (Partikel Radikal Hidroksil yang Terkandung dalam Air)
Melalui penelitian kolaboratif dengan Profesor Asosiasi Mayo Yasugi dari Sekolah Pascasarjana Ilmu Kedokteran Hewan, Osaka Metropolitan University, telah terungkap untuk pertama kalinya bahwa kerusakan struktur SARS-CoV-2 merupakan salah satu penyebab inaktivasi virus melalui paparan nanoe™.
nanoe™ melumpuhkan seluruh virus
nanoe™ menempel di permukaan virus, merusak protein pada permukaan sel termasuk protein tonjolan yang membuat virus terikat pada sel, serta merusak selubungnya.
Degradasi protein secara progresif pada permukaan virus dan kerusakan pada selubung memperluas perubahan struktur virus. Selubungnya rusak.
Degradasi protein internal, termasuk protein nukleokapsid dan RNA genom virus. Virus ini hancur berkeping-keping.
Proses mana yang menunjukkan kerja nanoe™ dalam menghambat mekanisme infeksi SARS CoV-2?
Cara SARS-CoV-2 menginfeksi sel
1. Virus mendekati sel inang
2. Virus berikatan dengan reseptor sel inang
3. Virus menyerang sel inang dan bereplikasi
Apa yang terjadi jika nanoe™ ikut serta?
1. Virus dihancurkan berkeping-keping oleh efek nanoe™
2. Virus yang dihancurkan berkeping-keping tidak dapat berikatan dengan sel
3. Karena tidak ada ikatan, virus tidak dapat menyerang ke dalam sel dan tidak terjadi infeksi
Dengan nanoe™, virus tertentu menjadi kehilangan efektivitas untuk dapat menular
nanoe™ tidak menargetkan molekul atau struktur virus tertentu, tetapi merusak SARS-CoV-2 dengan melakukan beberapa aksi bertahap pada selubung, protein, dan RNA genom yang membentuk virus. Virus yang rusak akibat paparan nanoe™ kehilangan kemampuannya untuk berikatan dengan reseptor sel inang, sehingga menjadi kehilangan efektivitas untuk dapat menular. Rangkaian fenomena ini dianggap sebagai bagian dari cara SARS-CoV-2 menjadi tidak aktif akibat kinerja nanoe™.
Makalah tentang mekanisme inaktivasi SARS-CoV-2 oleh nanoe™
*1 Sebagai teknologi pemurnian udara emisi ion (data Panasonic per 8 Juni 2022)
Menghambat aktivitas bakteri1-3 & virus4-6 yang
menempel di udara
Beberapa bakteri dan virus terlalu kecil untuk dilihat
Perbedaan ukuran antara bakteri dan virus tertentu hampir setara dengan perbedaan antara apel dan biji wijen.
Virus ini bertahan dalam periode yang bervariasi pada permukaan yang berbeda
Masa bertahan hidup bervariasi tergantung permukaan, dari 3 jam hingga 7 hari.
|
Jenis zat |
Periode bertahan hidup |
|
---|---|---|---|
|
Kertas, tisu |
3 jam |
|
|
Permukaan tembaga* |
4 jam |
|
|
Permukaan karton |
24 jam |
|
|
Permukaan kain |
2 hari |
|
|
Permukaan plastik |
3 hari |
|
|
Permukaan kaca |
4 hari |
|
|
Permukaan uang kertas |
4 hari |
|
|
Sisi luar masker bedah |
7 hari |
|
*Tembaga secara alami mendegradasi bakteri dan virus tertentu.
Masa bertahan hidup berbeda tergantung ketidakteraturan permukaan.
Virus bertahan lebih lama di permukaan yang halus dibandingkan permukaan yang tidak beraturan. Sumber: https://www.businessinsider.com/coronavirus-lifespan-on-surfaces-graphic-2020-3
Efek pada bakteri & virus tertentu
Bakteri Staphylococcus aureus1
yang menyebar melalui udara
Virus bacteriophage Φχ1744
yang menyebar lewat udara
Bakteri yang menempel
O1572
Subtipe virus
influenza H1N1 yang melekat
MRSA3
Virus polio tipe1 (Lsc-2ab)6
Cara kerja nanoe™ X
nanoe™ X mencapai virus.
Radikal hidroksil mengubah sifat protein virus.
Aktivitas virus dihambat.1–6
1Bakteri yang menyebar melalui udara (Staphylococcus aureus). Organisasi penguji: Pusat Penelitian Ilmu Lingkungan Kitasato Metode pengujian: Jumlah bakteri diukur setelah paparan langsung dalam ruang uji kedap udara berukuran kurang lebih 25 m3. Metode penghambatan: nanoe™ dirilis. Zat sasaran: Bakteri yang menyebar melalui udara. Hasil uji: Dihambat setidaknya 99,7% dalam 4 jam. (24_0301_1)
2Bakteri yang menempel (O157). Organisasi penguji: Laboratorium Penelitian Makanan Jepang. Metode pengujian: Mengukur jumlah bakteri yang menempel pada kain dalam ruang uji kedap udara berukuran kurang lebih 45 L. Metode penghambatan: nanoe™ dirilis. Zat sasaran: Bakteri yang menempel. Hasil uji: Dihambat setidaknya 99,99% dalam 1 jam (208120880_001)
3Bakteri yang melekat (MRSA). Organisasi penguji: Japan Food Research Laboratories/Laboratorium Penelitian Makanan Jepang. Metode pengujian: Mengukur jumlah bakteri yang menempel pada kain dalam ruang uji kedap udara berukuran sekitar 45 L. Metode penghambatan: nanoe™ dirilis. Zat sasaran: Bakteri yang menempel. Hasil uji: Dihambat setidaknya 99,99% dalam 1 jam (208120880_002)
4Virus yang menyebar melalui udara (bacteriophageΦχ174). Organisasi penguji: Kitasato Research Center for Environmental Science/Pusat Penelitian Kitasato untuk Ilmu Pengetahuan Lingkungan Metode pengujian: Jumlah virus diukur setelah paparan langsung di ruang uji kedap udara berukuran kurang lebih 25 m3. Metode penghambatan: nanoe™ dirilis. Zat sasaran: Virus yang menular melalui udara. Hasil uji: Dihambat sebanyak 99,7% dalam 6 jam. (24_0300_1)
5Virus yang melekat (virus Influenza subtipe H1N1). Organisasi penguji: Kitasato Research Center for Environmental Science/Pusat Penelitian Kitasato untuk Ilmu Pengetahuan Lingkungan Metode pengujian: Mengukur jumlah virus yang menempel pada kain di ruang uji kedap udara berukuran kurang lebih 1 m3. Metode penghambatan: nanoe™ dirilis. Zat sasaran: Virus yang melekat. Hasil uji: Dihambat sebanyak 99,9% dalam 2 jam. (21_0084_1)
6Virus yang melekat (Poliovirus type1(Lsc-2ab)). Organisasi penguji: Kitasato Research Center for Environmental Science/Pusat Penelitian Kitasato untuk Ilmu Pengetahuan Lingkungan Metode pengujian: Mengukur jumlah virus yang menempel pada kain di ruang uji kedap udara berukuran sekitar 45 L. Metode penghambatan: nanoe™ dirilis. Zat sasaran: Virus yang melekat. Hasil uji: Dihambat sebanyak 99,7% dalam 2 jam. (22_0096)
Hasil dapat berbeda tergantung penggunaan, variabel musim dan lingkungan (suhu dan kelembapan). nanoe™ X dan nanoe™ menghambat aktivitas atau pertumbuhan virus, tetapi tidak mencegah penyakit.
Bukti
Virus
nanoe™
|
Target |
Results*¹ |
Test space |
Exposure |
Testing organisation |
Report No. |
|
---|---|---|---|---|---|---|---|
Adhering |
Novel coronavirus |
99.7% |
45 L |
3 |
Osaka Prefecture University |
|
|
Bird flu virus |
99.9% |
45 L |
4 |
Obihiro University of Agriculture |
|
||
Swine-origin influenza virus |
99% |
45 L |
6 |
||||
Influenza virus |
99.9% |
45 L |
4 |
Japan Food Research Laboratories |
208040534-001 |
||
99.9% |
1,000 L |
2 |
Kitasato Research Center |
21_0084_1 |
|||
Bacteriophage |
99.9% |
10,000 L |
24 |
Kitasato Research Center |
21_0143_4 |
||
99.8% |
Approx. |
8 |
Japan Food Research Laboratories |
13001265005-01 |
|||
Coxackievirus |
99.1% |
45 L |
2 |
Kitasato Research Center |
22_0085 |
||
Poliovirus type 1 |
99.7% |
45 L |
2 |
22_0096 |
|||
Encephalomyocarditis virus |
99.9% |
45 L |
6 |
Charles River Biopharmaceutical |
Virus clearance test |
||
Porcineparvovirus |
99.7% |
45 L |
6 |
||||
Xenotropic murine leukemia virus |
99.999% |
45 L |
6 |
||||
Pseudororabies virus |
99.9% |
45 L |
6 |
||||
Canine distemper virus |
99.7% |
45 L |
4 |
Rakuno Gakuen University, |
|
||
Canine parvovirus |
99.8% |
45 L |
6 |
||||
Canine herpesvirus |
99.5% |
45 L |
4 |
||||
Canine adenovirus |
99.4% |
45 L |
4 |
Yamaguchi University, |
|
||
Feline coronavirus |
99.3% |
45 L |
2 |
||||
Feline calicivirus |
99.9% |
25 L |
2 |
Japan Food Research Laboratories |
207031493-001 |
||
Airborne |
Bacteriophage |
99% |
1,000 L |
1.5 |
Kitasato Research Center |
20_0154_1 |
|
99.2% |
10,000 L |
4 |
21_0147 |
||||
99.74% |
Approx. |
6 |
24_0300_1 |
nanoe™ X
|
Target |
Results*¹ |
Test space |
Exposure |
Testing organisation |
Report No. |
|
---|---|---|---|---|---|---|---|
Adhering |
Novel coronavirus |
99.7% |
45 L |
0.2 |
Osaka Prefecture University |
|
|
99.9% |
45 L |
0.2 |
Texcell |
1140-01 A1 |
|||
91.4% |
6.7 m³ |
0.5 |
1140-01 C3 |
||||
Bird flu virus |
99.9% |
45 L |
2 |
Obihiro University of Agriculture |
|
||
Swine-origin influenza virus |
99% |
45 L |
2 |
||||
Influenza virus |
99.9% |
1,000 L |
2 |
Kitasato Research Center |
21_0084_1 |
||
Bacteriophage |
99.9% |
10,000 L |
2 |
Kitasato Research Center |
21_0143_4 |
||
99.8% |
Approx. |
2 |
Japan Food Research Laboratories |
13001265005-01 |
|||
Coxackievirus |
99.1% |
45 L |
2 |
Kitasato Research Center |
22_0085 |
||
Poliovirus type 1 |
99.7% |
45 L |
2 |
22_0096 |
|||
Encephalomyocarditis virus |
99.9% |
45 L |
2 |
Charles River Biopharmaceutical |
Virus clearance test |
||
Porcineparvovirus |
99.7% |
45 L |
1 |
||||
Xenotropic murine leukemia virus |
99.999% |
45 L |
1 |
||||
Pseudororabies virus |
99.9% |
45 L |
6 |
||||
Canine distemper virus |
99.7% |
45 L |
4 |
Rakuno Gakuen University, |
|
||
Canine parvovirus |
99.8% |
45 L |
6 |
||||
Canine herpesvirus |
99.5% |
45 L |
4 |
||||
Canine adenovirus |
99.4% |
45 L |
4 |
Yamaguchi University, |
|
||
Feline coronavirus |
99.3% |
45 L |
2 |
||||
Feline calicivirus |
99.9% |
25 L |
2 |
Japan Food Research Laboratories |
207031493-001 |
||
Enterovirus 71 |
99.1% |
61 L |
4 |
Wuhan Institute of Virology, CAS |
MVCCC-2019/T4 |
||
99.9% |
61 L |
6 |
|||||
Coxsackievirus A16 |
99.3% |
61 L |
2 |
Wuhan Institute of Virology, CAS |
MVCCC-2019/T4 |
||
99.9% |
61 L |
4 |
|||||
Human coronavirus |
99.2% |
68 L |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00465 |
||
Airborne |
Bacteriophage |
99% |
1,000 L |
1.5 |
Kitasato Research Center |
20_0154_1 |
|
99.2% |
10,000 L |
4 |
21_0147 |
||||
99.2% |
Approx. |
6 |
24_0300_1 |
nanoe™ X (nanoe™ X Generator Mark 2)
|
Target |
Results*¹ |
Test space |
Exposure |
Testing organisation |
Report No. |
|
---|---|---|---|---|---|---|---|
Adhering |
Enterohemorrhagic Escherichia coli |
99.99% |
45 L |
1 |
Japan Food Research Laboratories |
208120880-001 |
|
99.99% |
45 L |
2 |
Eurofins |
2010/456-3 |
|||
Enterohemorrhagic |
99.99% |
45 L |
2 |
2010/456-4 |
|||
Methicillin-resistant Staphylococcus aureus |
99.99% |
45 L |
1 |
Japan Food Research Laboratories |
208120880-002 |
||
99.99% |
45 L |
1 |
Eurofins |
2010/456-1 |
|||
99.99% |
45 L |
2 |
Osaka Prefecture University |
|
|||
Escherichia coli |
99.99% |
45 L |
2 |
Panasonic Product Analysis Center |
E02-080303IN-01 |
||
Staphylococcus aureus |
99.99% |
1,000 L |
2 |
Kitasato Research Center |
20_0154_2 |
||
99.2% |
10,000 L |
2 |
Panasonic Product Analysis Center |
E02-090701IN-01 |
|||
99% |
10,000 L |
2 |
Japan Food Research Laboratories |
209071031-001 |
|||
99.1% |
Approx. |
2 |
13044083003-01 |
||||
99% |
Approx. |
1 |
SGS |
SHES160600431171 |
|||
Multiple-drug-resistant Pseudomonas aeruginosa |
99% |
45 L |
1 |
Toho University Faculty of Medicine, |
|
||
Multi-drug resistant Acinetobacter baumannii |
99% |
45 L |
2 |
||||
Bacillus |
99.7% |
45 L |
1 |
Japan Food Research Laboratories |
11000924001-01 |
||
Micrococcus |
99.9% |
45 L |
0.5 |
11000924001-02 |
|||
Serratia |
99.9% |
45 L |
0.5 |
11000924001-03 |
|||
Kocuria |
99.9% |
45 L |
0.5 |
11000922001-01 |
|||
methicillin-resistant staphylococcus pseudintermedius |
99.5% |
45 L |
0.5 |
Nippon Medical School, |
|
||
Bordetella bronchiseptica |
99.9% |
45 L |
0.5 |
||||
Pasteurella multocida |
99.9% |
45 L |
1 |
||||
Listeria monocytogenes |
99.9% |
45 L |
2 |
Osaka Prefecture University |
|
||
Bacillus subtilis |
99.9% |
45 L |
4 |
||||
Mycobacterium smegmatis |
99.9% |
45 L |
4 |
||||
Nocardia asteroids |
99.9% |
45 L |
4 |
||||
Neisseria gonorrhoeae |
99.9% |
45 L |
1 |
||||
Salmonella enterica |
99.9% |
45 L |
2 |
||||
Haemophilus influenza |
99.9% |
45 L |
1 |
||||
Campylobacter jejuni |
99.9% |
45 L |
4 |
||||
Airborne |
Staphylococcus aureus |
99.9% |
1,000 L |
0.34 |
Kitasato Research Center |
20_0154_1 |
|
99% |
10,000 L |
4 |
21_0142 |
||||
99.9% |
10,000 L |
3 |
21_0044 |
||||
99.7% |
Approx. |
4 |
24_0301_1 |
nanoe™ X (nanoe™ X Generator Mark 3)
Bakteri
nanoe™
|
Target |
Results*¹ |
Test space |
Exposure |
Testing organisation |
Report No. |
|
---|---|---|---|---|---|---|---|
Adhering |
Enterovirus (EV71) |
99.9% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00439 |
|
Enterovirus (EV71) |
99.9% |
30 m³ |
6 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00439 |
||
Enterovirus (EV71) |
97.6% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J1911WT8888-04860-01 |
||
Enterovirus (EV71) |
99.9% |
30 m³ |
6 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00453 |
||
Coxsackie virus (CA16) |
99.9% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00439 |
||
Coxsackie virus (CA16) |
99.9% |
30 m³ |
6 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00439 |
||
Coxsackie virus (CA16) |
95.4% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J1911WT8888-004860-02 |
||
Coxsackie virus (CA16) |
99.9% |
30 m³ |
6 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00453 |
||
Coronavirus (HCoV-229E) |
99.9% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00544-01 |
||
Coronavirus (HCoV-229E) |
99.9% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00889 |
||
Herpes simplex virus |
99.9% |
30 m³ |
4 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00889 |
||
Airborne |
Enterovirus (EV71) |
95.4% |
30 m³ |
1.5 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00439 |
|
Enterovirus (EV71) |
96.9% |
30 m³ |
1.5 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00889 |
||
Influenza virus (H1N1) |
95.4% |
30 m³ |
1.5 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2002WT8888-00439 |
||
Influenza virus (H1N1) |
98.3% |
30 m³ |
1.5 |
China Electronic Product Reliability and Environmental Testing Research Institute |
J2003WT8888-00889 |
nanoe™ X
|
Target |
Results*¹ |
Test space |
Exposure |
Testing organisation |
Report No. |
|
---|---|---|---|---|---|---|---|
Adhering |
Enterohemorrhagic Escherichia coli |
99.99% |
45 L |
1 |
Japan Food Research Laboratories |
208120880-001 |
|
99.9% |
45 L |
2 |
Eurofins |
2010/456-3 |
|||
Enterohemorrhagic |
99.99% |
45 L |
2 |
2010/456-4 |
|||
Methicillin-resistant Staphylococcus aureus |
99.99% |
45 L |
1 |
Japan Food Research Laboratories |
208120880-002 |
||
99.99% |
45 L |
1 |
Eurofins |
2010/456-1 |
|||
99.9% |
45 L |
2 |
Osaka Prefecture University |
|
|||
Escherichia coli |
99.9% |
45 L |
1 |
Panasonic Product Analysis Center |
E02-080303IN-01 |
||
Staphylococcus aureus |
99.99% |
1,000 L |
0.34 |
Kitasato Research Center |
20_0154_2 |
||
99.2% |
10,000 L |
24 |
Panasonic Product Analysis Center |
E02-090701IN-01 |
|||
99% |
10,000 L |
24 |
Japan Food Research Laboratories |
209071031-001 |
|||
99.1% |
Approx. |
8 |
13044083003-01 |
||||
99% |
Approx. |
8 |
SGS |
SHES160600431171 |
|||
99.91% |
24 m³ |
8 |
Panasonic Product Analysis Center |
1V332-170703-F04 |
|||
Multiple-drug-resistant Pseudomonas aeruginosa |
99% |
45 L |
2 |
Toho University Faculty of Medicine, |
|
||
Multi-drug resistant Acinetobacter baumannii |
99% |
45 L |
2 |
||||
Bacillus |
99.7% |
45 L |
0.5 |
Japan Food Research Laboratories |
11000924001-01 |
||
Micrococcus |
99.9% |
45 L |
2 |
11000924001-02 |
|||
Serratia |
99.9% |
45 L |
2 |
11000924001-03 |
|||
Kocuria |
99.9% |
45 L |
1 |
11000922001-01 |
|||
methicillin-resistant staphylococcus pseudintermedius |
99.5% |
45 L |
2 |
Nippon Medical School, |
|
||
Bordetella bronchiseptica |
99.9% |
45 L |
2 |
||||
Pasteurella multocida |
99.9% |
45 L |
1 |
||||
Listeria monocytogenes |
99.9% |
45 L |
2 |
Osaka Prefecture University |
|
||
Bacillus subtilis |
99.9% |
45 L |
4 |
||||
Mycobacterium smegmatis |
99.9% |
45 L |
4 |
||||
Nocardia asteroids |
99.9% |
45 L |
4 |
||||
Neisseria gonorrhoeae |
99.9% |
45 L |
1 |
||||
Salmonella enterica subsp. enterica |
99.9% |
45 L |
2 |
||||
Haemophilus influenza |
99.9% |
45 L |
1 |
||||
Campylobacter jejuni |
99.9% |
45 L |
4 |
||||
Airborne |
Staphylococcus aureus |
99.9% |
1,000 L |
0.34 |
Kitasato Research Center |
20_0154_1 |
|
99% |
10,000 L |
4 |
21_0142 |
||||
99.9% |
10,000 L |
3 |
21_0044 |
||||
99.7% |
Approx. |
4 |
24_0301_1 |